The Black Stars will line-up in a 4-2-3-1 formation with Inaki Williams coming on to replace Jordan Ayew to lead the lines.
Lawrence Ati Zigi remains in post.
Ali Seidu maintains his spot in the starting 11 as a right-back after a man-of-the-match display at the Accra Sports Stadium last Friday.
Gideon Mensah takes the left-back position, as Alexander Djiku and Mohammed Salisu continue their partnership as the two center-backs.
Atalanta midfielder, Ibrahim Sulemana joins Elisha Owusu for his second Black Stars start as the two midfielders.
Captain Mohammed Kudus slots in behind Inaki with Antoine Semenyo and Ernest Nuamah playing wide.
Black Stars hope to secure first win
The starting 11 have to come to the party if Ghana have any chance of qualifying for the tournament in Morocco next year.
The Black Stars hope to secure their first win of the 2025 Africa Cup of Nations (AFCON) after failing to do so in the first three games.
Addoβs team have been wasteful upfront and that hurt them in their goalless draw at home against Sudan, putting them in a position of a must-win today.
The former Borussia Dortmund talent development coach believes his team will find the back of the net today.
This is Ghana's starting 11 against Sudan:
Lawrence Ati Zigi
Ali Seidu
Alexander Djiku
Mohammed Salisu
Gideon Mensah
Ibrahim Sulemana
Elisha Owusu
Antoine Semenyo
Ernest Nuamah
Mohammed Kudus
Inaki Williams