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The Arsenal midfielder has been struggling with niggling injuries since the start of the season, which has seen him play just a few games.
The 30-year-old had just returned from a groin injury but suffered a setback in training and is now set to be sidelined for over a month.
Fresh reports suggest the Ghana international has undergone a specialist procedure for treatment on a thigh injury and will now miss the rest of the year.
Partey wasn’t named in Ghana’s squad for the upcoming 2026 FIFA World Cup qualifiers against Madagascar and Comoros.
The Black Stars will take on Madagascar on Friday, November 17, before travelling to face Comoros four days later.
Meanwhile, Arsenal boss Mikel Arteta has confirmed that Partey “will be out for weeks” after his latest injury setback.
"I think he will be out for weeks. I don't know how long but he's got another appointment today [and] we will see more after that," he said.
"Yes, [his injury record] is a big concern because when Thomas is fit and available and has been a part of the team we see the results and impact he has on the team.
"This season we've had more protection, especially for that reason because we know in the last two seasons what had happened and the impact that had on the team. We have to address it."
Meanwhile, Partey is also likely to miss next year’s AFCON, which is set to start on January 13, 2024.