The Arsenal midfielder started in the reverse fixture in Kumasi last Thursday but his place has now been taken by in the starting line-up by Salis Abdul Samed.
Inaki Williams has also dropped to the bench, with Semenyo, who netted the winner in last week’s game, getting the nod in attack.
Meanwhile, Lawrence Ati Zigi maintains his position in post, with debutant Kingsley Schindler replacing the injured Denis Odoi at right-back.
Daniel Amartey is the captain for the day and will partner Edmund Addo in a pivot, while Kamaldeen Sulemana, Mohammed Kudus and Jordan Ayew will provide support for Semenyo.
See Ghana’s starting line-up against Angola below:
Lawrence Ati Zigi
Kingsley Schindler
Gideon Mensah
Joseph Aidoo
Daniel Amartey
Edmund Addo
Salis Abdul Samed
Jordan Ayew
Mohammed Kudus
Kamaldeen Sulemana
Antoine Semenyo