Jordan Ayew has made a return to the starting line-up, with Antoine Semenyo, Ernest Nuamah and Tariq Lamptey all dropping to the bench.
Aside from Ayew, Abdul Fatawu Issahaku has also been rewarded with a start following his lively cameo against Mali last Thursday.
Addo has also reverted to a back four, with Alidu Seidu, Gideon Mensah, Alexander Djiku and Mohammed Salisu protecting Lawrence Ati-Zigi in the post.
Thomas Partey, who will once again captain the team, has also been paired with Abdul Salis Samed in midfield, with Sulemana and Issahaku operating from the flanks.
Mohammed Kudus has also been maintained from the team that beat Mali 2-1 four days ago in Bamako, while Ayew will lead the attack after coming off the bench to score against the Eagles.
See Ghana’s starting line-up against the Central African Republic (CAR) below:
Lawrence Ati-Zigi
Alidu Seidu
Gideon Mensah
Alexander Djiku
Mohammed Salisu
Thomas Partey
Abdul Salis Samed
Mohammed Kudus
Kamaldeen Sulemana
Abdul Fatawu Sulemana
Jordan Ayew