The fire started around 1 am and destroyed shops and other properties on Wednesday at midnight.
An eyewitness John Ofori told Accra-based Citi FM that "We saw the smoke from afar, so we thought it was the GCB bank but it was instead coming from the market. It took the Fire Service about two hours to douse the fire."
This is not the first time the Odawna Market has witnessed a destructive fire.