The address, which is slated for 8:00 pm, will be the President’s 20th since Ghana recorded its first COVID-19 case.
The country has come a long way from March when the first two cases were recorded, however, the number of daily infections has reduced in recent months.
Akufo-Addo last addressed the nation on November 11, where he cautioned that Ghanaians were letting their guard down.
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He noted that some citizens were failing to adhere to social distancing protocols, as well as wearing face masks and hand-washing.
He also used the opportunity to announce that all health workers will pay no income taxes on their salaries till the end of the year.
Tonight’s address will be Akufo-Addo’s first since he was successfully re-elected to a second term in office.
The 76-year-old, who contested as the New Patriotic Party’s (NPP) presidential candidate, won the election after polling 51.30% of the total votes cast.
His main rival, Mahama of the opposition NDC also managed to poll 47.36% of the total votes cast.
Meanwhile, Ghana’s total COVID-19 case count currently stands at 53,653, although the active cases are 991.
Also, 52,331 infected persons have been discharged, while the respiratory disease has claimed 331 lives.