The accident occurred on Friday, 11th January 2018.
Seven persons who sustained injuries are receiving treatment at the Ejisu Government Hospital, where the bodies of the deceased have also been deposited.
An eyewitness told 3news: "“We rushed to the scene of the accident only to find that some passengers on the Sprinter bus have had their heads, legs were cut off,” he said.
The accident occurred when the sprinter bus overtook another vehicle on a speed ramp and collided head-on with an articulated truck, causing the truck to veer off the road before crashing into a building.
The frontage of the Sprinter bus and the right side were mangled and some section of the body ripped.