Three other persons injured and rushed to the Tema General Hospital.
An eyewitness said the driver of the vehicle failed to brake and veered off the road.
READ MORE: Demonstration looms on Tema motorway over deadly potholes
The incident occurred at the KICC junction at about 7:30 am when a Hyundai truck with registration number GT 1547 – 14 run into some pedestrians killing one on the spot.
The deceased, according to reports, identified as Ophelia is said to be a worker with Royal Crown Packaging, a subsidiary of Kasapreko Company and a resident of Ashaiman.
The three injured persons are in critical condition.