Avram Grant and his men could seal a place in the 2017 Africa Cup of Nations tournament in the game against Mauritius.
The team made the 10-hour trip aboard the Pan African Airline ASKY, landing in the Mauritius capital St. Port Louis.
The Black Stars left Ghana on Friday despite an earlier schedule plan of a departure last Wednesday.
Ghana are the leaders of Group H with 10 points, needing just a single point against Mauritius to qualify for the 2017 Africa Cup of Nations tournament in Gabon.