Black Stars settled for a one all draw against South Africa at the Moses Mabhida Sports Stadium, Durban on Tuesday in a friendly international.
Ghana went into the lead on 38 minutes of game play, after Harison Afful was brought down and Mubarak Wakaso stepped up to break the deadlock.
The Bafana Bafana with defeat staring them right in the face, fought back and pulled even in the 51st minute: Ayanda Patosi drew level for the hosts with a shot from the edge of the box.
Ghana made four changes to the team that drew goalless at home against Uganda on Friday in their opening group E 2018 FIFA World Cup qualifying game in Tamale.
Adam Kwarasey replaced Razak Braimah in post, while Thomas Partey was given the opportunity to partner Mubarak Wakaso in midfield in the absence of the injured Afriyie Acquah, with Majid Maris and Samuel Tetteh thrown into attack to replace Asamoah Gyan and Jordan Ayew.
Asamoah Gyan came on in the 82nd minute, while Gilbert Koomson was handed his Black Stars debut when he replaced Christian Atsu.
Ghana after the defeat have gone four consecutive games without a win (D3, L1).
Mubarak Wakaso was named man of the match.