Odubajo suffered the serious knee injury during a non-contact incident in training, Premier League newcomers Hull confirmed in a statement on Thursday.
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Serious knee injury sidelines Hull's Odubajo
Hull City are expected to be without Moses Odubajo for six months after the full-back fractured his patella.
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While Odubajo's knee ligaments remain intact, the 23-year-old will undergo surgery next week to stabilise the fracture.
It is another blow for Odubajo, who was on the comeback trail after dislocating his patella during the off-season.
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