Januzaj, on loan from Manchester United, suffered the injury in his side's 3-2 loss to Crystal Palace on Saturday.
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Adnan Januzaj blow for Sunderland in Premier League
Sunderland attacker Adnan Januzaj is set to miss at least six weeks due to an ankle injury.
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Scans confirmed the 21-year-old suffered ankle ligament damage, the club confirmed on Tuesday.
The club said Januzaj had been ruled out for a minimum of six weeks.
He has made six Premier League appearances for struggling Sunderland, who are bottom of the table with just one point.
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David Moyes' men host West Brom on Saturday.
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