A 0-0 draw against Antigua GFC on a wet Tuesday in Guatemala was enough for the Red Bulls to seal top spot in Group F.
CONCACAF Champions League Review: Red Bulls progress
The New York Red Bulls booked their spot in the CONCACAF Champions League quarter-finals, while the Portland Timbers left it late.
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Jesse Marsch's men are on eight points, six clear of Antigua and Alianza.
Mike Grella squandered a chance for the Red Bulls, while substitute Mauro Portillo missed the best opportunity for the hosts in the second half.
Jorge Zaldivar made a brilliant last-ditch clearance to deny the visitors, but a point was enough for the Red Bulls.
In El Salvador, the Timbers had a thrilling 2-1 victory over Dragon.
After Fanendo Adi cancelled out Kevin Melara's opener, Darlington Nagbe was the hero with a late winner.
The Timbers are second to Deportivo Saprissa, who hold a one-point lead atop Group B.
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