Late drama at Villa Park as Atsu's side were denied a win by Ayew's Aston Villa
Aaron Tshibola claimed a hard-fought point for Villa from a 1-1 draw with an 88th-minute header.
Tommy Elphick had given United a first-half lead with an own goal, and Rafa Benitez's side looked to be heading for a victory at Villa Park.
But Tshibola rose to head a cross from Jordan Ayew past Matz Sels in the dying minutes to the frustration of Benitez and the club's 2,800 travelling fans.
Ayew played the full throttle of the game whiles his teammate Adomah made his first start since joining Aston Villa from Middlesbrough last summer but was subbed off for Rudy Gestede in the 62nd minute. Atsu on the other hand was an unused substitute for Newcastle.
It was also the first time two Champions League winning managers – Benitez and Roberto Di Matteo – had gone head to head in English football's second tier.