His opponents have accused him of lacking the political will to fight corruption among officials close to him.
He said through the sunlight policy, corruption has been fought, exposed and prosecuted.
"Our government has been candid and transparent with the people of Ghana," he said. "We have applied the most potent disinfectant in fighting corruption which is exposure, sunlight. That is the sunlight policy to expose."
He said unlike the kufour administration, he will expose, investigate and prosecute corrupt officials when necessary.
He said: "Unlike in previous government, we have not declared that we will not expose corruption and bring down our government. We will expose corruption wherever we find it. And It will also be investigated wherever we find it and when necessary we have commenced investigations of persons who have indulged in corruption.
"We'll make corruption to continue to be high-risk activity. We will diligently continue implementation of the national anti-corruption action plan while applying ICT to remove as much human discretion in public financial management."
A conflict of interest charge was also labelled against him by the Minority in Parliament after it emerged that he received a Ford car gift from a Burkinabe contractor.
Annually, Ghana loses $3 billion in corruption activities, according to policy think tank, IMANI Africa.