President Mahama cut the sod for the construction of the three-tier interchange at the Kwame Nkrumah Circle in Accra
The GH₵320.2 million project was jointly financed by the Brazilian government and the government of Ghana.
Read related: Mahama to inaugurate Nkrumah interchange on Monday
A statement issued by the Ministry of Roads and Highways, said the opening was necessary to reduce congestion and allow traffic to flow freely at the interchange and its environs.
The statement asked the drivers of big trucks to, as a matter of urgency, observe the height restrictions when using the Interchange, and also tasked traders to transact business at authorised locations.
It said: "Law enforcement officers would not countenance any encroachment on the aforementioned routes", warning that trespassers would be dealt with and appropriate sanctions applied where necessary.
"The general public, both motorists and pedestrians are strictly advised to observe all road traffic regulations and obey the law enforcement officials to make driving on the new Kwame Nkrumah interchange safe and smooth for all," it added.
The Kwame Nkrumah Circle is a key intersection in the major road network in Accra.
More here: Kwame Nkrumah Circle to be opened to traffic
It carries about 84,000 vehicles a day and constitutes a key bottleneck in the major road network that links the suburban areas of Accra to the central business district.
Aside from the three-tier interchange, other roads around the Kwame Nkrumah Circle will be improved. These include rehabilitation of the Ring Road East to the Feo Oyo Intersection on the Ring Road West.